In the pursuit of healthy ageing, scientists have uncovered key cellular processes that influence how we age. One of the most exciting discoveries in longevity research is the role of sirtuins, a family of proteins that regulate cellular health, metabolism, and DNA repair. Boosting sirtuin activity is believed to be essential for slowing down ageing, improving energy production, and promoting long-term well-being.

In this guide, we will explore how sirtuins impact the ageing process and how longevity supplements in the UK and sirtuin-boosting foods can support their function.

What Are Sirtuins and Why Do They Matter?

Sirtuins are a group of seven proteins (SIRT1–SIRT7) that play a crucial role in cellular repair, inflammation control, and metabolic health. These proteins are activated in response to stress, fasting, and calorie restriction, helping cells function optimally and survive longer.

One of the most important factors for sirtuin activation is NAD+ (nicotinamide adenine dinucleotide), a coenzyme that declines with age. Without sufficient NAD+ levels, sirtuins become less effective, leading to faster cellular ageing, mitochondrial dysfunction, and increased inflammation.

By consuming sirtuin-boosting foods and NAD+ supporting longevity supplements, it is possible to enhance sirtuin activity and promote anti-ageing benefits at a cellular level.

Best Sirtuin-Boosting Foods for Longevity

Certain foods naturally enhance sirtuin activity and help maintain healthy ageing. Incorporating these into your diet can provide antioxidants, polyphenols, and essential nutrients that support sirtuin function:

• Dark Chocolate and Cocoa – Rich in polyphenols, particularly resveratrol, which stimulates SIRT1 activation.
• Green Tea – Contains catechins that protect cells from oxidative stress and support metabolism.
• Olive Oil – High in healthy monounsaturated fats and oleuropein, which may enhance sirtuin activity.
• Turmeric – The active compound curcumin has strong anti-inflammatory and sirtuin-activating properties.
• Blueberries – Packed with anthocyanins and flavonoids that protect DNA and boost sirtuin function.
• Walnuts – A source of polyphenols and omega-3 fatty acids that support brain health and longevity.
• Cruciferous Vegetables (Broccoli, Kale, Brussels Sprouts) – Contain sulforaphane, which activates SIRT1 and helps detoxify the body.
• Red Grapes – Rich in resveratrol, a key sirtuin-activating compound.

Including these foods regularly can support sirtuin activation, reduce oxidative stress, and promote longevity naturally.

Top Longevity Supplements in the UK for Sirtuin Activation

While diet plays a crucial role, longevity supplements can provide additional support to optimise NAD+ levels and enhance sirtuin activity. Here are some of the best supplements available in the UK for sirtuin boosting and anti-ageing:

1. NAD+ Precursors (Nicotinamide Riboside and NMN)

• Why? NAD+ is essential for sirtuin function, but levels decline with age. Supplementing with nicotinamide riboside (NR) can help restore NAD+ levels, keeping sirtuins active.
• How to take? Daily supplementation with Muto Longevity can support energy production, cognitive function, and cellular repair.

2. Pterostilbene

• Why? These powerful polyphenols are found in red grapes and blueberries. They work synergistically with NAD+ to enhance sirtuin activation.
• How to take? Found in Muto Longevity, it is best taken alongside NAD+ boosters for optimal benefits.

3. Quercetin and Fisetin

• Why? These senolytic compounds help clear out damaged senescent cells that contribute to ageing and inflammation. Quercetin also helps regulate the immune system and supports overall cellular health.
• How to take? Combined with a healthy diet, they can slow age-related decline.

4. Curcumin (Turmeric Extract)

• Why? Curcumin is a natural anti-inflammatory that activates SIRT1 and protects cells from oxidative damage.
• How to take? Look for a supplement with piperine (black pepper extract) to enhance absorption.

5. Vitamin D3 and K2

• Why? These vitamins support mitochondrial health, bone density, and immune function, all of which are crucial for longevity.
• How to take? Best taken together to maximise absorption and benefits.

Lifestyle Habits That Enhance Sirtuin Function

Beyond diet and supplements, certain lifestyle habits can naturally boost sirtuin activity and support anti-ageing:

1. Intermittent Fasting

Caloric restriction and fasting have been shown to increase sirtuin activation, promoting longevity and metabolic health. A 16:8 fasting schedule (fasting for 16 hours and eating within an 8-hour window) can help trigger these benefits.

2. Regular Exercise

Strength training, high-intensity workouts, and endurance exercises stimulate sirtuins and improve mitochondrial function. Aim for a mix of cardio, resistance training, and mobility exercises.

3. Stress Management

Chronic stress leads to inflammation and oxidative damage. Practising meditation, breathwork, or mindfulness can help lower stress levels and support cellular health.

4. Prioritising Quality Sleep

Sirtuins play a key role in regulating circadian rhythms. A consistent sleep schedule, minimising blue light exposure before bed, and ensuring deep restorative sleep can optimise sirtuin function.

Final Thoughts on Sirtuin Boosting for Longevity

Sirtuins are essential for healthy ageing, cellular repair, and longevity. By incorporating sirtuin-boosting foods, NAD+ precursors, and longevity supplements available in the UK, it is possible to support anti-ageing at a cellular level.

For those looking to enhance their longevity routine, focusing on NAD+ restoration, polyphenols, and anti-inflammatory compounds is a science-backed approach to maintaining health and vitality for years to come.