Ageing is a complex process influenced by cellular function, inflammation, and oxidative stress. One of the most exciting breakthroughs in longevity science is the discovery of senolytics, compounds that help remove senescent cells and promote healthier ageing. If you’re looking for UK supplements for longevity, particularly those supporting NAD+ levels and cellular health, senolytics could be a game-changer.

Understanding Senescent Cells and Ageing

As we age, some cells enter a state called cellular senescence, meaning they stop dividing but don’t die off as they should. These “zombie cells” accumulate over time, releasing inflammatory molecules that contribute to ageing and age-related diseases. This can lead to:

• Increased inflammation (inflammageing)
• Reduced NAD+ levels and mitochondrial dysfunction
• Slower cellular repair and regeneration
• Higher risk of chronic conditions such as cardiovascular disease and cognitive decline

Senolytics are compounds that target and eliminate these senescent cells, helping to restore youthful cellular function and support healthy ageing.

How Do Senolytics Work?

Senolytic compounds selectively clear out senescent cells without harming healthy cells. By reducing the buildup of these dysfunctional cells, senolytics can help:

• Improve cellular energy production by supporting mitochondrial function
• Reduce inflammation and oxidative stress
• Enhance skin health and collagen production
• Support NAD+ metabolism for sustained energy and longevity

Best Senolytic Supplements for Longevity in the UK

If you’re looking to incorporate senolytic supplements into your routine, here are some of the most promising ingredients backed by science:

1. Quercetin

A powerful flavonoid found in foods like onions and apples, quercetin is a natural senolytic that helps remove senescent cells. It also supports cardiovascular health and has antioxidant properties to combat oxidative stress.

2. Fisetin

Fisetin, found in strawberries and other fruits, has been identified as one of the most potent natural senolytics. It helps promote cellular renewal, reduce inflammation, and improve mitochondrial function.

3. NAD+ Boosters (NR)

While not senolytics themselves, NAD+ precursors like Nicotinamide Riboside (NR) help maintain cellular energy and DNA repair. These compounds support the effects of senolytics by ensuring efficient cell metabolism and function.

4. Curcumin

A well-known anti-inflammatory compound from turmeric, curcumin has been shown to help modulate senescence-related inflammation and oxidative stress.

5. Pterostilbene

These polyphenols activate sirtuins, proteins involved in DNA repair and cellular longevity. Resveratrol and pterostilbene also enhance the effects of NAD+ boosting supplements, supporting mitochondrial function and healthy ageing.

How to Use Senolytic Supplements for Maximum Benefits

1. Follow a Cyclical Dosing Schedule

Research suggests that senolytics work best when taken intermittently, rather than daily. This means taking these supplements in cycles (e.g., one or two days a week) to clear senescent cells without affecting normal cell function.

2. Combine with NAD+ Boosters

Since cellular ageing is linked to declining NAD+ levels, combining senolytics with NAD+ precursors like NR can enhance overall benefits by supporting mitochondrial health and energy production.

3. Adopt a Longevity-Focused Lifestyle

To maximise the effects of senolytic supplements, consider incorporating other healthy ageing strategies, such as:

• Intermittent fasting to stimulate autophagy (cellular cleanup)
• Exercise (especially resistance training) to promote mitochondrial function
• A nutrient-rich diet high in antioxidants, polyphenols, and healthy fats

The Future of Senolytics and Anti-Ageing Science

Senolytics represent one of the most promising advancements in longevity research, offering a novel way to combat ageing at the cellular level. As the science evolves, more UK-based longevity supplements are integrating these compounds to help people live healthier, longer lives.

By incorporating senolytics, NAD+ boosters, and antioxidants, you can take proactive steps to improve your cellular health and slow down ageing naturally.

Looking for the Best Longevity Supplements in the UK?

Discover premium NAD+ supplements and senolytic formulas designed to support healthy ageing and cellular health. Explore our science-backed formulations today!